This is a "hands-on" lecture/workshop intended for the designer/ artist/therapist of the interactive system for "wellness entertainment". In recent years, the fields of serious games and medical/welfare/ rehabilitation applications are gaining attention in the field of entertainment computing. The organizer of this workshop has been promoting R & D activities in this area for over 20 years, and recently targeting "Wellness" or "Well-being" entertainment using bio-sensing technology. This lecture/workshop contains four parts of practical techniques/ideas to realize effective interactive system for "wellness entertainment" - environment & interface, concept of biofeedback, special techniques using commercial bio-sensors and cutting-edge topics.